New approaches in the development of Hypoallergenic implant material in Orthopaedics: steps to personalised medicine – HypOrth

New approaches in the development of Hypoallergenic implant material in Orthopaedics: steps to personalised medicine – HypOrth 

“Nowe rozwiązania w opracowaniu hipoalergicznego materiału na implanty ortopedyczne: kroki ku spersonalizowanej medycynie – HypOrth“

Akronym: HypOrth
Time of project implementation: 2013–2018

EU contribution for Metal Forming Institute: EUR 404.291,00
MNiSW contribution for Metal Forming Institute: PLN 508 781,00

Project’s Partners:

• Otto-von-Guericke-Universitaet Magdeburg (Germany) – Coordinator,
• ARTTIC International Management Services (France),
• Instytut Obróbki Plastycznej (Poland),
• Mathys AG Bettlach (Switzerland),
• Progenika Biopharma SA (Spain),
• Research Centre for NaturalSciencesHungarianAcademy of Sciences (Hungary),
• Tartu Ulikool (Estonia),
• Teknologisk Institut (Denmark).

The main goal of HypOrth project is to identify adverse immune reactions to orthopaedic implant material and to find remedial strategies against chronic adverse reactions and the development of an endoprosthetic prototype based on hypoallergenic and antibacterial materials and the definition of individual predictive and general diagnostic biomarkers for AIR.

Overall, HypOrth helped to improve the diagnosis and prevention of AIR in total joint arthroplasty. New prototypes will provide options for potential new biomaterials or surface modifications for total joint arthroplasties that will prevent AIR. Further, profiling patients and assessing cytokine profiles will help to establish markers to prevent or to diagnose AIR.

The Institute participates in the tasks: WP8. Study of material associations and the implant prototype i WP10: Development of an implant prototype with hypoallergenic and antibacterial properties.

This project has received funding from the European Union’s 7th Programme for research, technological development and demonstration under grant agreement No 602398.

Project’s website: http://www.hyporth.eu